Yes. The Virginia Breeze route, operated by Megabus, stops at Squires Student Center, near the Alumni Mall entrance in Blacksburg, VA, and Blacksburg Transit Center, Bus Bay #1, 1324 Perry Street in Blacksburg, VA. It then travels to Union Station in Washington, DC with stops in between.
For the most accurate and up-to-date information, you can visit the Virginia Breeze website.
Virginia Breeze/Megabus: Blacksburg, VA - Bus Stops